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Glyphosate and AMPA levels in human urine samples and their correlation with food consumption: results of the cross-sectional KarMeN study in Germany

Soukup, Sebastian T.; Merz, Benedikt; Bub, Achim; Hoffmann, Ingrid; Watzl, Bernhard; Steinberg, Pablo; Kulling, Sabine E.

Abstract (englisch):
Glyphosate (N-[phosphonomethyl]-glycine) is the most widely used herbicide worldwide. Due to health concerns about
glyphosate exposure, its continued use is controversially discussed. Biomonitoring is an important tool in safety evaluation
and this study aimed to determine exposure to glyphosate and its metabolite AMPA, in association with food consumption
data, in participants of the cross-sectional KarMeN study (Germany). Glyphosate and AMPA levels were measured in 24-h
urine samples from study participants (n = 301). For safety evaluation, the intake of glyphosate and AMPA was calculated
based on urinary concentrations and checked against the EU acceptable daily intake (ADI) value for glyphosate. Urinary
excretion of glyphosate and/or AMPA was correlated with food consumption data. 8.3% of the participants (n = 25) exhibited
quantifiable concentrations (> 0.2 μg/L) of glyphosate and/or AMPA in their urine. In 66.5% of the samples, neither
glyphosate (< 0.05 μg/L) nor AMPA (< 0.09 μg/L) was detected. The remaining subjects (n = 76) showed traces of glyphosate
and/or AMPA. The calculated glyphosate and/or AMPA intake was far below the ADI of glyphosate. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000118393
Veröffentlicht am 21.04.2020
Originalveröffentlichung
DOI: 10.1007/s00204-020-02704-7
Scopus
Zitationen: 8
Web of Science
Zitationen: 5
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 0340-5761, 1432-0738
KITopen-ID: 1000118393
Erschienen in Archives of toxicology
Verlag Springer
Band 94
Heft 5
Seiten 1575–1584
Vorab online veröffentlicht am 30.03.2020
Schlagwörter Glyphosate, Biomonitoring, Urine, Food consumption, Correlation, Human
Nachgewiesen in Scopus
Web of Science
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