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Regioselective Functionalization of [2.2]Paracyclophanes: Recent Synthetic Progress and Perspectives

Hassan, Zahid; Spuling, Eduard; Knoll, Daniel M.; Bräse, Stefan

Abstract:
[2.2]Paracyclophane (PCP) is a prevalent scaffold that is widely utilized in asymmetric synthesis, p-stacked polymers, energy materials, and functional parylene coatings that finds broad applications in bioand materials science. In the last few years, [2.2]paracyclophane chemistry has progressed tremendously, enabling the fine-tuning of ist structural and functional properties. This Minireview highlights the most important recent synthetic developments in the selective functionalization of PCP that govern distinct features of planar chirality as well as chiroptical and optoelectronic properties. Special focus is given to the function-inspired design of [2.2]paracyclophane-based pstacked conjugated materials by transition-metal-catalyzed crosscoupling reactions. Current synthetic challenges, limitations, as well as future research directions and new avenues for advancing cyclophane chemistry are also summarized.

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Verlagsausgabe §
DOI: 10.5445/IR/1000118463
Veröffentlicht am 17.04.2020
Originalveröffentlichung
DOI: 10.1002/anie.201904863
Scopus
Zitationen: 2
Web of Science
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Organische Chemie (IOC)
Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 02.2020
Sprache Englisch
Identifikator ISSN: 1433-7851, 1521-3773
KITopen-ID: 1000118463
Erschienen in Angewandte Chemie / International edition
Band 59
Heft 6
Seiten 2156–2170
Vorab online veröffentlicht am 08.07.2019
Nachgewiesen in Web of Science
Scopus
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