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The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Gröschel, Matthias I.; Meehan, Conor J.; Barilar, Ivan; Diricks, Margo; Gonzaga, Aitor; Steglich, Matthias; Conchillo-Solé, Oscar; Scherer, Isabell-Christin; Mamat, Uwe; Luz, Christian F.; De Bruyne, Katrien; Utpatel, Christian; Yero, Daniel; Gibert, Isidre; Daura, Xavier; Kampmeier, Stefanie; Rahman, Nurdyana Abdul; Kresken, Michael; van der Werf, Tjip S.; Alio, Ifey; ... mehr

Abstract (englisch):
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.

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Verlagsausgabe §
DOI: 10.5445/IR/1000118761
Veröffentlicht am 28.04.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 2041-1723
KITopen-ID: 1000118761
HGF-Programm 47.02.06 (POF III, LK 01)
Zellpopul.auf Biofunk.Oberflächen IFG
Erschienen in Nature Communications
Band 11
Heft 1
Seiten Article No. 2044
Vorab online veröffentlicht am 27.04.2020
Nachgewiesen in Web of Science
Scopus
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