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DNA Helicases as Safekeepers of Genome Stability in Plants

Dorn, Annika; Puchta, Holger

Abstract:
Genetic information of all organisms is coded in double-stranded DNA. DNA helicases are essential for unwinding this double strand when it comes to replication, repair or transcription of genetic information. In this review, we will focus on what is known about a variety of DNA helicases that are required to ensure genome stability in plants. Due to their sessile lifestyle, plants are especially exposed to harmful environmental factors. Moreover, many crop plants have large and highly repetitive genomes, making them absolutely dependent on the correct interplay of DNA helicases for safeguarding their stability. Although basic features of a number of these enzymes are conserved between plants and other eukaryotes, a more detailed analysis shows surprising peculiarities, partly also between different plant species. This is additionally of high relevance for plant breeding as a number of these helicases are also involved in crossover control during meiosis and influence the outcome of different approaches of CRISPR/Cas based plant genome engineering. Thus, gaining knowledge about plant helicases, their interplay, as well as the manipulation of their pathways, possesses the potential for improving agriculture. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000118770
Veröffentlicht am 28.04.2020
Originalveröffentlichung
DOI: 10.3390/genes10121028
Scopus
Zitationen: 1
Web of Science
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Botanisches Institut (BOTANIK)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 2073-4425
KITopen-ID: 1000118770
Erschienen in Genes
Verlag MDPI
Band 10
Heft 12
Seiten Art.Nr. 1028
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Gefördert vom Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (MWK) im Rahmen des Open-Access-Förderprogramms "BW BigDIWA"
Vorab online veröffentlicht am 10.12.2019
Schlagwörter DNA recombination; DNA repair; crossover; gene targeting; helicase; meiosis
Nachgewiesen in Scopus
Web of Science
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