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Detection and imaging of gadolinium accumulation in human bone tissue by micro- and submicro-XRF

Turyanskaya, Anna; Rauwolf, Mirjam; Pichler, Vanessa; Simon, Rolf; Burghammer, Manfred; Fox, Oliver J. L.; Sawhney, Kawal; Hofstaetter, Jochen G.; Roschger, Andreas; Roschger, Paul; Wobrauschek, Peter; Streli, Christina

Abstract:
Gadolinium-based contrast agents (GBCAs) are frequently used in patients undergoing magnetic resonance imaging. In GBCAs gadolinium (Gd) is present in a bound chelated form. Gadolinium is a rare-earth element, which is normally not present in human body. Though the blood elimination half-life of contrast agents is about 90 minutes, recent studies demonstrated that some tissues retain gadolinium, which might further pose a health threat due to toxic effects of free gadolinium. It is known that the bone tissue can serve as a gadolinium depot, but so far only bulk measurements were performed. Here we present a summary of experiments in which for the first time we mapped gadolinium in bone biopsy from a male patient with idiopathic osteoporosis (without indication of renal impairment), who received MRI 8 months prior to biopsy. In our studies performed by means of synchrotron radiation induced micro- and submicro-X-ray fluorescence spectroscopy (SR-XRF), gadolinium was detected in human cortical bone tissue. The distribution of gadolinium displays a specific accumulation pattern. Correlation of elemental maps obtained at ANKA synchrotron with qBEI images (quantitative backscattered electron imaging) allowed assignment of Gd structures to the histological bone structures. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000119644
Veröffentlicht am 14.10.2020
Originalveröffentlichung
DOI: 10.1038/s41598-020-63325-9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Photonenforschung und Synchrotronstrahlung (IPS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2020
Sprache Englisch
Identifikator ISSN: 2045-2322
KITopen-ID: 1000119644
HGF-Programm 56.03.30 (POF III, LK 01) Soft Matter, Health and Life Sciences
Erschienen in Scientific reports
Verlag Nature Research
Band 10
Heft 1
Seiten Art.Nr.: 6301
Vorab online veröffentlicht am 14.04.2020
Nachgewiesen in Scopus
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