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Detection and imaging of gadolinium accumulation in human bone tissue by micro- and submicro-XRF

Turyanskaya, Anna; Rauwolf, Mirjam; Pichler, Vanessa; Simon, Rolf; Burghammer, Manfred; Fox, Oliver J. L.; Sawhney, Kawal; Hofstaetter, Jochen G.; Roschger, Andreas; Roschger, Paul; Wobrauschek, Peter; Streli, Christina

Gadolinium-based contrast agents (GBCAs) are frequently used in patients undergoing magnetic resonance imaging. In GBCAs gadolinium (Gd) is present in a bound chelated form. Gadolinium is a rare-earth element, which is normally not present in human body. Though the blood elimination half-life of contrast agents is about 90 minutes, recent studies demonstrated that some tissues retain gadolinium, which might further pose a health threat due to toxic effects of free gadolinium. It is known that the bone tissue can serve as a gadolinium depot, but so far only bulk measurements were performed. Here we present a summary of experiments in which for the first time we mapped gadolinium in bone biopsy from a male patient with idiopathic osteoporosis (without indication of renal impairment), who received MRI 8 months prior to biopsy. In our studies performed by means of synchrotron radiation induced micro- and submicro-X-ray fluorescence spectroscopy (SR-XRF), gadolinium was detected in human cortical bone tissue. The distribution of gadolinium displays a specific accumulation pattern. Correlation of elemental maps obtained at ANKA synchrotron with qBEI images (quantitative backscattered electron imaging) allowed assignment of Gd structures to the histological bone structures. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000119644
Veröffentlicht am 14.10.2020
DOI: 10.1038/s41598-020-63325-9
Zitationen: 11
Zitationen: 12
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Photonenforschung und Synchrotronstrahlung (IPS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2020
Sprache Englisch
Identifikator ISSN: 2045-2322
KITopen-ID: 1000119644
HGF-Programm 56.03.30 (POF III, LK 01) Soft Matter, Health and Life Sciences
Erschienen in Scientific reports
Verlag Nature Research
Band 10
Heft 1
Seiten Art.Nr.: 6301
Vorab online veröffentlicht am 14.04.2020
Nachgewiesen in Scopus
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