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Dual sequence definition increases the data storage capacity of sequence-defined macromolecules

Wetzel, Katharina S. 1,2; Frölich, Maximiliane 1,2; Solleder, Susanne C. 1,2; Nickisch, Roman ORCID iD icon 1,2; Treu, Philipp ORCID iD icon 1,2; Meier, Michael A. R. 1,2
1 Laboratorium für Applikationen der Synchrotronstrahlung (LAS), Karlsruher Institut für Technologie (KIT)
2 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)


Sequence-defined macromolecules offer applications in the field of data storage. Challenges include synthesising precise and pure sequences, reading stored information and increasing data storage capacity. Herein, the synthesis of dual sequence-defined oligomers and their application for data storage is demonstrated. While applying the well-established Passerini three-component reaction, the degree of definition of the prepared monodisperse macromolecules is improved compared to previous reports by utilising nine specifically designed isocyanide monomers to introduce backbone definition. The monomers are combined with various aldehyde components to synthesise dual-sequence defined oligomers. Thus, the side chains and the backbones of these macromolecules can be varied independently, exhibiting increased molecular diversity and hence data storage capacity per repeat unit. In case of a dual sequence-defined pentamer, 33 bits are achieved in a single molecule. The oligomers are obtained in multigram scale and excellent purity. Sequential read-out by tandem ESI-MS/MS verifies the high data storage capacity of the prepared oligomers per repeat unit in comparison to other sequence defined macromolecules.

Verlagsausgabe §
DOI: 10.5445/IR/1000120011
Veröffentlicht am 05.06.2020
DOI: 10.1038/s42004-020-0308-z
Zitationen: 24
Zitationen: 28
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2020
Sprache Englisch
Identifikator ISSN: 2399-3669
KITopen-ID: 1000120011
HGF-Programm 47.01.01 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Erschienen in Communications chemistry
Verlag Nature Research
Band 3
Heft 1
Seiten Art. Nr.: 63
Vorab online veröffentlicht am 20.05.2020
Nachgewiesen in Scopus
Web of Science
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