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A New Synthetic Conduit for the Treatment of Peripheral Nerve Injuries

Uranues, Selman; Bretthauer, Georg; Tomasch, Gordana; Rafolt, Dietmar; Nagele-Moser, Doris; Berghold, Andrea; Kleinert, Reinhold; Justich, Ivo; Waldert, Jörg; Koch, Horst

Abstract:
Background
Peripheral nerve defects (PND) often cause lifelong physical disability, and the available treatment options are often not satisfactory. PND are usually bridged with an autologous nerve transplant or a nerve guidance conduit (NGC), when coaptation as preferred technique is not possible. The aim of this experimental study was to determine the effectiveness of a novel NGC for regeneration in the treatment of PND.
Materials and methods
A conduit made of gelatin with an innovative interior structure was tested for the repair of a 6-mm gap versus direct microsurgical suture repair without gap.
Results
We found that bridging the defect with this conduit was as effective as direct microsurgical coaptation without a defect.
Conclusions
This nerve conduit, effective in bridging neural defects, appears as an alternative to autologous nerve grafts, avoiding the problems related to nerve graft harvesting, host–donor differences in diameter, mismatches in number and pattern of fascicles, cross-sectional shape and area, and morbidity of the donor area.

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Verlagsausgabe §
DOI: 10.5445/IR/1000120839
Veröffentlicht am 02.07.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 0364-2313, 1432-2323
KITopen-ID: 1000120839
HGF-Programm 47.01.02 (POF III, LK 01)
Biol.Netzwerke u.Synth.Regulat. IAI
Erschienen in World journal of surgery
Vorab online veröffentlicht am 08.06.2020
Nachgewiesen in Web of Science
Scopus
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