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Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities

Silva, A. M.; Martins-Gomes, C.; Souto, E. B.; Schäfer, J. 1; Santos, J. A.; Bunzel, M. 1; Nunes, F. M.
1 Institut für Angewandte Biowissenschaften (IAB), Karlsruher Institut für Technologie (KIT)

Abstract (englisch):

Thymus zygis subsp. zygis is an endemic Portuguese plant belonging to the Thymus zygis species. Although T. zygis is commonly used as a condiment and as a medicinal herb, a detailed description of the polyphenol composition of hydroethanolic (HE) and aqueous decoction (AD) extracts is not available. In this work, we describe for the first time a detailed phenolic composition of Thymus zygis subsp. zygis HE and AD extracts, together with their antioxidant, anti-proliferative and anti-inflammatory activities. Unlike other Thymus species, T. zygis subsp. zygis extracts contain higher amounts of luteolin-(?)-O-hexoside. However, the major phenolic compound is rosmarinic acid, and high amounts of salvianolic acids K and I were also detected. T. zygis subsp. zygis extracts exhibited significant scavenging activity of ABTS+, hydroxyl (•OH), and nitric oxide (NO) radicals. Regarding the anti-proliferative/cytotoxic effect, tested against Caco-2 and HepG2 cells, the AD extract only slightly reduced cell viability at higher concentrations (IC50 > 600 µg/mL, 48 h exposure), denoting very low toxicity, while the HE extract showed a high anti-proliferative effect, especially at 48 h exposure (IC50 of 85.01 ± 15.10 μg/mL and 82.19 ± 2.46 μg/mL, for Caco-2 and HepG2, respectively). ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000120985
Veröffentlicht am 08.07.2020
DOI: 10.3390/antiox9060482
Zitationen: 28
Zitationen: 27
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 2076-3921
KITopen-ID: 1000120985
Erschienen in Antioxidants
Verlag MDPI
Band 9
Heft 6
Seiten Article No. 482
Vorab online veröffentlicht am 03.06.2020
Schlagwörter Thymus zygis subsp. zygis; phenolic profiling; aqueous decoction; hydroethanolic extract; luteolin-O-hexoside; anti-proliferative activity; radical scavenging activity; antioxidant; anti-inflammatory activity
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