In this paper, we show that cluster validation indices can be used for filtering mislabeled instances or class outliers prior to training in supervised learning problems. We propose a technique, entitled Cluster Validation Index (CVI)-based Outlier Filtering, in which mislabeled instances are identified and eliminated from the training set, and a classification hypothesis is then built from the set of remaining instances. The proposed approach assigns each instance several cluster validation scores representing its potential of being an outlier with respect to the clustering properties the used validation measures assess. We examine CVI-based Outlier Filtering and compare it against the Local Outlier Factor (LOF) detection method on ten data sets from the UCI data repository using five well-known learning algorithms and three different cluster validation indices. In addition, we study and compare three different approaches for combining the selected cluster validation measures. Our results show that for most learning algorithms and data sets, the proposed CVI-based outlier filtering algorithm outperforms the baseline method (LOF). The greatest increase in classification accuracy has been achieved by using union or ranked-based median strategies to assemble the used cluster validation indices and global filtering of mislabeled instances.