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A One‐Step Biofunctionalization Strategy of Electrospun Scaffolds Enables Spatially Selective Presentation of Biological Cues

Wieringa, Paul; Girao, Andre; Ahmed, Maqsood; TruckenmÜller, Roman; Welle, Alexander; Micera, Silvestro; Wezel, Richard; Moroni, Lorenzo

Abstract:
To recapitulate the heterogeneous complexity of tissues in the human body with synthetic mimics of the extracellular matrix (ECM), it is important to develop methods that can easily allow the selective functionalization of defined spatial domains. Here, a facile method is introduced to functionalize microfibrillar meshes with different reactive groups able to bind biological moieties in a one‐step reaction. The resulting scaffolds prove to selectively support a differential neurite growth after being seeded with dorsal root ganglia. Considering the general principles behind the method developed, this is a promising strategy to realize enhanced biomimicry of native ECM for different regenerative medicine applications.

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Verlagsausgabe §
DOI: 10.5445/IR/1000122817
Veröffentlicht am 19.08.2020
Originalveröffentlichung
DOI: 10.1002/admt.202000269
Web of Science
Zitationen: 3
Dimensions
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 10.2020
Sprache Englisch
Identifikator ISSN: 2365-709X, 2365-709X
KITopen-ID: 1000122817
HGF-Programm 47.02.06 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IFG
Erschienen in Advanced materials technologies
Verlag John Wiley and Sons
Band 5
Heft 10
Seiten Art.Nr. 2000269
Vorab online veröffentlicht am 05.08.2020
Schlagwörter KNMF 2014-011-003105 ToF-SIMS
Nachgewiesen in Scopus
Dimensions
Web of Science
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