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Association of Locomotor Activity During Sleep Deprivation Treatment With Response

Foo, J. C.; Sirignano, L.; Trautmann, N.; Kim, J.; Witt, S. H.; Streit, F.; Frank, J.; Zillich, L.; Meyer-Lindenberg, A.; Ebner-Priemer, U.; Schilling, C.; Schredl, M.; Yamamoto, Y.; Gilles, M.; Deuschle, M.; Rietschel, M.

Abstract:
Disrupted circadian rhythms and sleep patterns are frequently observed features of psychiatric disorders, and especially mood disorders. Sleep deprivation treatment (SD) exerts rapid but transient antidepressant effects in depressed patients and has gained recognition as a model to study quick-acting antidepressant effects. It is of interest how locomotor activity patterns during SD might be associated with and potentially predict treatment response. The present study is an analysis of locomotor activity data, previously collected over a 24 h period, to examine the night of SD (Trautmann et al. 2018) as mood disorder patients suffering from a depressive episode (n = 78; after exclusions n = 59) underwent SD. In this exploratory analysis, the associations between response to SD, locomotor activity, and subjective mood during the 24 h period of SD were explored. Higher levels of activity overall were observed in non-responders (n = 18); in particular, non-responders moved more during the evening of SD until midnight and remained high thereafter. In contrast, activity in responders (n = 41) decreased during the evening and increased in the morning. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000123294
Veröffentlicht am 04.09.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1664-0640
KITopen-ID: 1000123294
Erschienen in Frontiers in psychiatry
Verlag Frontiers Media
Band 11
Seiten Art.-Nr.: 688
Schlagwörter locomotor activity, sleep deprivation treatment, depression, mood, treatment response
Nachgewiesen in Dimensions
Web of Science
Scopus
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