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Valorization of Crude Glycerol into Citric Acid and Malic Acid by Yarrowia lipolytica

Qian, Xiujuan; Xu, Ning; Jing, Yiwen; Song, Meng; Zhou, Jie; Dong, Weiliang; Xin, Fengxue; Zhang, Wenming; Jiang, Min; Ochsenreither, Katrin

Abstract (englisch):
Glycerol is a byproduct generated in large amounts during the process of biodiesel production. The present study reports an alternative method of crude glycerol valorization for the production of citric and malic acid by Yarrowia lipolytica. To enhance the conversion efficiency, we comprehensively investigated optimization of the carbon source, nitrogen source, and pH regulation strategy. Under optimal conditions with the initial concentration of crude glycerol at 40 g/L in combination with 0.3 g/L NH4Cl as the nitrogen source and pH at 4.0 using Na2CO3, we finally obtained 81.11 g/L citric acid and 24.90 g/L malic acid using fed-batch fermentation. In addition, acetate was found to enhance organic acid production and regulate carbon flow among organic acids from crude glycerol. The present study provides an alternative approach for valorization of crude glycerol into value-added biochemicals.



Originalveröffentlichung
DOI: 10.1021/acs.iecr.0c01723
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 0888-5885, 1520-5045
KITopen-ID: 1000123548
Erschienen in Industrial & engineering chemistry research
Seiten A - H
Vorab online veröffentlicht am 10.08.2020
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