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DNA–Polymer Nanostructures by RAFT Polymerization and Polymerization-Induced Self-Assembly

Lückerath, T.; Koynov, K.; Loescher, S.; Whitfield, C. J.; Nuhn, L.; Walther, A.; Barner-Kowollik, C.; Ng, D. Y. W.; Weil, T.

Abstract:
Nanostructures derived from amphiphilic DNA–polymer conjugates have emerged prominently due to their rich self‐assembly behavior; however, their synthesis is traditionally challenging. Here, we report a novel platform technology towards DNA–polymer nanostructures of various shapes by leveraging polymerization‐induced self‐assembly (PISA) for polymerization from single‐stranded DNA (ssDNA). A “grafting from” protocol for thermal RAFT polymerization from ssDNA under ambient conditions was developed and utilized for the synthesis of functional DNA–polymer conjugates and DNA–diblock conjugates derived from acrylates and acrylamides. Using this method, PISA was applied to manufacture isotropic and anisotropic DNA–polymer nanostructures by varying the chain length of the polymer block. The resulting nanostructures were further functionalized by hybridization with a dye‐labelled complementary ssDNA, thus establishing PISA as a powerful route towards intrinsically functional DNA–polymer nanostructures.

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Verlagsausgabe §
DOI: 10.5445/IR/1000123600
Veröffentlicht am 27.09.2020
Originalveröffentlichung
DOI: 10.1002/anie.201916177
Scopus
Zitationen: 1
Web of Science
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Technische Chemie und Polymerchemie (ITCP)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 01.09.2020
Sprache Englisch
Identifikator ISSN: 0044-8249, 0570-0833, 1433-7851, 1521-3757, 1521-3773
KITopen-ID: 1000123600
Erschienen in Angewandte Chemie / International edition
Band 59
Heft 36
Seiten 15474-15479
Vorab online veröffentlicht am 17.04.2020
Nachgewiesen in Scopus
Web of Science
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