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Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications

Hu, Yong; Domínguez, Carmen M.; Christ, Sophina; Niemeyer, Christof M.

Abstract:
We report on the directed postsynthetic functionalization of soft DNA nanocomposite materials with proteins. Using the example of the functionalization of silica nanoparticle‐modified DNA polymer materials with agonists or antagonists of the epidermal growth factor receptor EGFR cell membrane receptor, we demonstrate that hierarchically structured interfaces to living cells can be established. Owing to the modular design principle, even complex DNA nanostructures can be integrated into the materials, thereby enabling the high‐precision arrangement of ligands on the lower nanometer length scale. We believe that such complex biohybrid material systems can be used for new applications in biotechnology.

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Verlagsausgabe §
DOI: 10.5445/IR/1000123739
Veröffentlicht am 10.11.2020
Originalveröffentlichung
DOI: 10.1002/anie.202008471
Scopus
Zitationen: 2
Dimensions
Zitationen: 3
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1433-7851, 1521-3773
KITopen-ID: 1000123739
HGF-Programm 47.02.01 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-1
Erschienen in Angewandte Chemie / International edition
Verlag John Wiley and Sons
Band 59
Heft 43
Seiten 19016–19020
Vorab online veröffentlicht am 18.07.2020
Nachgewiesen in Dimensions
Web of Science
Scopus
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