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Regeneration of β-Cyclodextrin Based Membrane by Photodynamic Disulfide Exchange — Steroid Hormone Removal from Water

Dong, Zheqin 1; Tagliavini, Matteo 2; Darmadi, Jason 1; Trouillet, Vanessa 3; Schäfer, Andrea I. 2; Levkin, Pavel A. ORCID iD icon 4
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)
2 Institute for Advanced Membrane Technology (IAMT), Karlsruher Institut für Technologie (KIT)
3 Karlsruhe Nano Micro Facility (KNMF), Karlsruher Institut für Technologie (KIT)
4 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)


The occurrence of steroid hormones in water and their serious impact on human and ecosystem demand high performance materials for efficient removal of such micropollutants. Here, an affinity membrane is developed for hormone removal with regenerable binding sites. By using photodynamic disulfides as a linker, UV induced detachment of β‐CD ligands from the membrane surface is demonstrated. The macroporous base membrane is first fabricated via a polymerization induced phase separation method using 2‐hydroxyethyl methacrylate (HEMA) and ethylene dimethylacrylate (EDMA) monomers. Then the affinity membranes are prepared by immobilizing β‐CD ligands to the poly(HEMA‐co‐EDMA) base membrane through the 2‐carboxyethyl disulfide linker. The β‐CD functionalized affinity membrane shows a 30% increase of E2 hormone uptake compared with the base membrane, attributed to the formation of CD‐hormone host–guest inclusion complexes. The photodynamic disulfide linkers enable UV‐induced detachment of blocked β‐CD ligands from and reattachment of fresh β‐CD ligands to the membrane surface after each adsorption cycle, thus conferring the affinity membrane with excellent regenerative properties. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000125346
Veröffentlicht am 28.10.2020
DOI: 10.1002/admi.201902100
Zitationen: 10
Web of Science
Zitationen: 8
Zitationen: 8
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Materialien – Energiespeichersysteme (IAM-ESS)
Institute for Advanced Membrane Technology (IAMT)
Institut für Biologische und Chemische Systeme (IBCS)
Institut für Organische Chemie (IOC)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 19.11.2020
Sprache Englisch
Identifikator ISSN: 2196-7350
KITopen-ID: 1000125346
HGF-Programm 47.01.01 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Weitere HGF-Programme 12.02.03 (POF III, LK 01) Regional Climate-and Water Cycle Variab.
Erschienen in Advanced materials interfaces
Verlag John Wiley and Sons
Band 7
Heft 22
Seiten Art.-Nr.: 1902100
Vorab online veröffentlicht am 28.09.2020
Schlagwörter KNMF 2019-023-027909
Nachgewiesen in Web of Science
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