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The Genetic Programs Specifying Kolmer–Agduhr Interneurons

Yang, L.; Wang, F.; Strähle, Uwe

Abstract:
Kolmer–Agduhr (KA) cells are a subgroup of interneurons positioned adjacent to the neurocoele with cilia on the apical surface protruding into the central canal of the spinal cord. Although KA cells were identified almost a century ago, their development and functions are only beginning to be unfolded. Recent studies have revealed the characteristics of KA cells in greater detail, including their spatial distribution, the timing of their differentiation, and their specification via extrinsic signaling and a unique combination of transcription factors in zebrafish and mouse. Cell lineage-tracing experiments have demonstrated that two subsets of KA cells, named KA’ and KA” cells, differentiate from motoneuronal progenitors and floor-plate precursors, respectively, in both zebrafish and mouse. Although KA’ and KA” cells originate from different progenitors/precursors, they each share a common set of transcription factors. Intriguingly, the combination of transcription factors that promote the acquisition of KA’ cell characteristics differs from those that promote a KA” cell identity. In addition, KA’ and KA” cells exhibit separable neuronal targets and differential responses to bending of the spinal cord. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000126028
Veröffentlicht am 30.11.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1662-453X, 1662-4548
KITopen-ID: 1000126028
HGF-Programm 47.01.01 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Erschienen in Frontiers in neuroscience
Verlag Frontiers Media
Band 14
Seiten Art.-Nr.: 577879
Vorab online veröffentlicht am 09.10.2020
Schlagwörter Kolmer–Agduhr cells, cerebrospinal fluid-contacting neurons, transcription factors, transcriptional regulatory network, GABAergic interneuron
Nachgewiesen in Dimensions
Scopus
Web of Science
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