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Quantification and classification of potassium and calcium disorders with the electrocardiogram: What do clinical studies, modeling, and reconstruction tell us?

Pilia, N. 1; Severi, S.; Raimann, J. G.; Genovesi, S.; Dössel, O. 1; Kotanko, P.; Corsi, C.; Loewe, A. ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)


Diseases caused by alterations of ionic concentrations are frequently observed challenges and play an important role in clinical practice. The clinically established method for the diagnosis of electrolyte concentration imbalance is blood tests. A rapid and non-invasive point-of-care method is yet needed. The electrocardiogram (ECG) could meet this need and becomes an established diagnostic tool allowing home monitoring of the electrolyte concentration also by wearable devices. In this review, we present the current state of potassium and calcium concentration monitoring using the ECG and summarize results from previous work. Selected clinical studies are presented, supporting or questioning the use of the ECG for the monitoring of electrolyte concentration imbalances. Differences in the findings from automatic monitoring studies are discussed, and current studies utilizing machine learning are presented demonstrating the potential of the deep learning approach. Furthermore, we demonstrate the potential of computational modeling approaches to gain insight into the mechanisms of relevant clinical findings and as a tool to obtain synthetic data for methodical improvements in monitoring approaches.

Verlagsausgabe §
DOI: 10.5445/IR/1000126486
Veröffentlicht am 23.11.2020
DOI: 10.1063/5.0018504
Zitationen: 10
Zitationen: 11
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 01.12.2020
Sprache Englisch
Identifikator ISSN: 2473-2877
KITopen-ID: 1000126486
Erschienen in APL bioengineering
Verlag American Institute of Physics (AIP)
Band 4
Heft 4
Seiten Art. Nr.: 041501
Vorab online veröffentlicht am 02.10.2020
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