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A genomic catalog of Earth’s microbiomes

Nayfach, S.; Roux, S.; Seshadri, R.; Udwary, D.; Varghese, N.; Schulz, F.; Wu, D.; Paez-Espino, D.; Chen, I.-M.; Huntemann, M.; Palaniappan, K.; Ladau, J.; Mukherjee, S.; Reddy, T. B. K.; Nielsen, T.; Kirton, E.; Faria, J. P.; Edirisinghe, J. N.; Henry, C. S.; Jungbluth, S. P.; ... mehr

The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.

Verlagsausgabe §
DOI: 10.5445/IR/1000126666
Veröffentlicht am 25.11.2020
DOI: 10.1038/s41587-020-0718-6
Zitationen: 76
Web of Science
Zitationen: 75
Zitationen: 137
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 0733-222X, 1087-0156, 1546-1696, 2331-3684
KITopen-ID: 1000126666
HGF-Programm 47.02.05 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-5
Erschienen in Nature biotechnology
Verlag Nature Research
Band 39
Seiten 499–509
Vorab online veröffentlicht am 09.11.2020
Nachgewiesen in Web of Science
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