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Physical Activity and Trajectory of Cognitive Change in Older Persons: Mayo Clinic Study of Aging

Krell-Roesch, Janina; Syrjanen, Jeremy A.; Bezold, Jelena; Trautwein, Sandra; Barisch-Fritz, Bettina; Boes, Klaus; Woll, Alexander ORCID iD icon; Forzani, Erica; Kremers, Walter K.; Machulda, Mary M.; Mielke, Michelle M.; Knopman, David S.; Petersen, Ronald C.; Vassilaki, Maria; Geda, Yonas E.


Background: Little is known about the association between physical activity (PA) and cognitive trajectories in older adults.

Objective: To examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) epsilon 4 status.

Methods: Longitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged >= 70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid- or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores.

Results: Light intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000126758
Veröffentlicht am 30.03.2021
DOI: 10.3233/JAD-200959
Zitationen: 7
Web of Science
Zitationen: 7
Zitationen: 10
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 05.01.2021
Sprache Englisch
Identifikator ISSN: 1387-2877, 1875-8908
KITopen-ID: 1000126758
Erschienen in Journal of Alzheimer's disease
Verlag IOS Press
Band 79
Heft 1
Seiten 377–388
Bemerkung zur Veröffentlichung Kollaboration: Mayo Clinic
Vorab online veröffentlicht am 13.11.2020
Nachgewiesen in Scopus
Web of Science
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