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Image analysis as PAT-Tool for use in extrusion-based bioprinting

Strauß, S.; Meutelet, R.; Radosevic, L.; Gretzinger, S.; Hubbuch, J.

Abstract (englisch):
The technology of bioprinting is arousing a growing interest in biopharmaceutical research and industry. In order to accelerate process development in the field of bioprinting, image-based analysis methods are non-invasive, time- and cost-saving tools which are useable for printer characterization, bioink printability evaluation, and process optimization. Image processing can also be used for the study of reproducibility, since reliable production is important in the transition from research to industrial application, and more precisely to clinical studies. This study revolves around the establishment of an automated and image-based line analysis method for bioprinting applications which enables an easy comparison of 3D-printed lines. Diverse rheological properties of bioinks and the printing process affect the geometry of the resulting object. The line represents a simple geometry, where the influence of the rheological properties and printing parameters is directly apparent. Therefore, a method for line analysis was developed on the basis of image recognition. At first, the method is tested for several substances such as Nivea®, pure and colored Kolliphor solutions, and two commercially available hydrogel formulations which can be used as bioinks. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000128196
Veröffentlicht am 22.01.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 31.03.2021
Sprache Englisch
Identifikator ISSN: 2405-8866
KITopen-ID: 1000128196
Erschienen in Bioprinting
Verlag Elsevier
Band 21
Seiten Art. Nr.: e00112
Schlagwörter Automated image processing, Line or extrusion characterization, Printing process, development, Bioprinting
Nachgewiesen in Scopus
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