Different vehicular speed limits may have an impact on the balance between safety and efficiency of travel on mountainous road corners associated with complex road conditions. Placing suitable speed limit warning signs does not merely effectively improve traffic safety but can also improve traffic efficiency. In this study, a global positioning system (GPS) terminal and Metrocount were used to collect vehicle speed data from more than 40 provincial-level curves in 8 provinces over the course of 1 year. Each road data collection time-period lasted approximately 8 hours. A descriptive statistics method was adopted by means of data screening and pretreatment. Additionally, both a velocity difference estimation model was established and a linear model of velocity differential estimation was constructed. Quantitative analysis was carried out on the safe speed, the driver’s expected speed, and the location of the speed limit warning signs. This demonstrated a positive correlation with the initial speed. When the difference in speed was greater than 15 km/h, a safety warning sign was required to limit the design speed to 80 km/h. A safety warning sign was also required when the corner radius was less than 300 m. ... mehrThe location of safety warning signs could be calculated based on the operating speed and taking driving safety and the visual range of drivers into consideration. The results can provide a theoretical reference for setting up appropriate safe speed limiting signs on road corners in mountainous areas.