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Combinatorial Fusion Rules to Describe Codon Assignment in the Standard Genetic Code

Nesterov-Mueller, Alexander 1; Popov, Roman 1; Seligmann, Hervé 1
1 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)

We propose combinatorial fusion rules that describe the codon assignment in the standard genetic code simply and uniformly for all canonical amino acids. These rules become obvious if the origin of the standard genetic code is considered as a result of a fusion of four protocodes: Two dominant AU and GC protocodes and two recessive AU and GC protocodes. The biochemical meaning of the fusion rules consists of retaining the complementarity between cognate codons of the small hydrophobic amino acids and large charged or polar amino acids within the protocodes. The proto tRNAs were assembled in form of two kissing hairpins with 9-base and 10-base loops in the case of dominant protocodes and two 9-base loops in the case of recessive protocodes. The fusion rules reveal the connection between the stop codons, the non-canonical amino acids, pyrrolysine and selenocysteine, and deviations in the translation of mitochondria. Using fusion rules, we predicted the existence of additional amino acids that are essential for the development of the standard genetic code. The validity of the proposed partition of the genetic code into dominant and recessive protocodes is considered referring to state-of-the-art hypotheses. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000128225
Veröffentlicht am 09.04.2021
DOI: 10.3390/life11010004
Zitationen: 2
Zitationen: 2
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 01.2021
Sprache Englisch
Identifikator ISSN: 2075-1729
KITopen-ID: 1000128225
HGF-Programm 47.01.03 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. IMT
Erschienen in Life
Verlag MDPI
Band 11
Heft 1
Seiten Art.-Nr. 4
Vorab online veröffentlicht am 23.12.2020
Nachgewiesen in Scopus
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