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Parkinson’s disease with restless legs syndrome - an in vivo corneal confocal microscopy study

Andréasson, Mattias; Lagali, Neil; Badian, Reza A.; Utheim, Tor Paaske; Scarpa, Fabio; Colonna, Alessia; Allgeier, Stephan ORCID iD icon 1; Bartschat, Andreas 1; Köhler, Bernd 1; Mikut, Ralf ORCID iD icon 1; Reichert, Klaus-Martin 2; Solders, Göran; Samuelsson, Kristin; Zetterberg, Henrik; Blennow, Kaj; Svenningsson, Per
1 Institut für Automation und angewandte Informatik (IAI), Karlsruher Institut für Technologie (KIT)
2 Karlsruher Institut für Technologie (KIT)

Abstract (englisch):

Small fiber neuropathy (SFN) has been suggested as a trigger of restless legs syndrome (RLS). An increased prevalence of peripheral neuropathy has been demonstrated in Parkinson’s disease (PD). We aimed to investigate, in a cross-sectional manner, whether SFN is overrepresented in PD patients with concurrent RLS relative to PD patients without RLS, using in vivo corneal confocal microscopy (IVCCM) and quantitative sensory testing (QST) as part of small fiber assessment. Study participants comprised of age- and sex-matched PD patients with (n = 21) and without RLS (n = 21), and controls (n = 13). Diagnosis of RLS was consolidated with the sensory suggested immobilization test. Assessments included nerve conduction studies (NCS), Utah Early Neuropathy Scale (UENS), QST, and IVCCM, with automated determination of corneal nerve fiber length (CNFL) and branch density (CNBD) from wide-area mosaics of the subbasal nerve plexus. Plasma neurofilament light (p-NfL) was determined as a measure of axonal degeneration. No significant differences were found between groups when comparing CNFL (p = 0.81), CNBD (p = 0.92), NCS (p = 0.82), and QST (minimum p = 0.54). ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000128860
Veröffentlicht am 22.01.2021
DOI: 10.1038/s41531-020-00148-5
Zitationen: 8
Web of Science
Zitationen: 7
Zitationen: 10
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 05.01.2021
Sprache Englisch
Identifikator ISSN: 2373-8057
KITopen-ID: 1000128860
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Weitere HGF-Programme 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in npj Parkinson's Disease
Verlag Nature Research
Band 7
Heft 1
Seiten Art.-Nr. 4
Projektinformation 3D-CCM (DFG, DFG EIN, MI 1315/5-2)
3D-CCM (DFG, DFG EIN, KO 5003/1-2)
Nachgewiesen in Scopus
Web of Science
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