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Atypical cellular elements of unknown origin in the subbasal nerve plexus of a diabetic cornea diagnosed by large-area confocal laser scanning microscopy

Sterenczak, Katharina A.; Stachs, Oliver; Marfurt, Carl; Matuszewska-Iwanicka, Aleksandra; Stratmann, Bernd; Sperlich, Karsten; Guthoff, Rudolf F.; Hettlich, Hans-Joachim; Allgeier, Stephan; Stahnke, Thomas

Abstract (englisch):
In vivo large-area confocal laser scanning microscopy (CLSM) of the human eye using EyeGuidance technology allows a large-scale morphometric assessment of the corneal subbasal nerve plexus (SNP). Here, the SNP of a patient suffering from diabetes and associated late complications was analyzed. The SNP contained multiple clusters of large hyperintense, stellate-shaped, cellular-like structures. Comparable structures were not observed in control corneas from healthy volunteers. Two hypotheses regarding the origin of these atypical structures are proposed. First, these structures might be keratocyte-derived myofibroblasts that entered the epithelium from the underlying stroma through breaks in Bowman’s layer. Second, these structures could be proliferating Schwann cells that entered the epithelium in association with subbasal nerves. The nature and pathophysiological significance of these atypical cellular structures, and whether they are a direct consequence of the patient’s diabetic neuropathy/or a non-specific secondary effect of associated inflammatory processes, are unknown.

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Verlagsausgabe §
DOI: 10.5445/IR/1000128861
Veröffentlicht am 22.01.2021
Originalveröffentlichung
DOI: 10.3390/diagnostics11020154
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 21.01.2021
Sprache Englisch
Identifikator ISSN: 2075-4418
KITopen-ID: 1000128861
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Weitere HGF-Programme 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Diagnostics
Verlag MDPI
Band 11
Heft 2
Seiten Article no: 154
Nachgewiesen in Dimensions
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