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Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Huang, Lin Chiang Sherlock; Le, Dao; Hsiao, I. Lun; Fritsch-Decker, Susanne; Hald, Christian; Huang, S.-C.; Chen, J.-K.; Hwu, J. R.; Weiss, C.; Hsu, M.-H.; Delaittre, Guillaume

Abstract:
Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

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Verlagsausgabe §
DOI: 10.5445/IR/1000129105
Veröffentlicht am 29.01.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Institut für Technische Chemie und Polymerchemie (ITCP)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 1759-9954, 1759-9962
KITopen-ID: 1000129105
Erschienen in Polymer chemistry
Verlag Royal Society of Chemistry (RSC)
Band 12
Heft 1
Seiten 50-56
Nachgewiesen in Dimensions
Scopus
Web of Science
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