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The infectious propagules of Aspergillus fumigatus are coated with antimicrobial peptides

Dümig, M.; Binder, J.; Gaculenko, A.; Daul, F.; Winandy, Lex; Hasenberg, M.; Gunzer, M.; Fischer, Reinhard; Künzler, M.; Krappmann, S.

Abstract:
Fungal spores are unique cells that mediate dispersal and survival in the environment. For pathogenic fungi encountering a susceptible host, these specialised structures may serve as infectious particles. The main causative agent of the opportunistic disease aspergillosis, Aspergillus fumigatus, produces asexual spores, the conidia, that become dissipated by air flows or water currents but also serve as propagules to infect a susceptible host. We demonstrate that the defX gene of this mould encodes putative antimicrobial peptides resembling cysteine‐stabilised (CS)$_{αβ}$ defensins that are expressed in a specific spatial and temporal manner in the course of asexual spore formation. Localisation studies on strains expressing a fluorescent proxy or tagged defX alleles expose that these antimicrobial peptides are secreted to coat the conidial surface. Deletion mutants reveal that the spore‐associated defX gene products delay the growth of Gram‐positive Staphylococcus aureus and demonstrate that the defX gene and presumably its encoded spore‐associated defensins confer a growth advantage to the fungal opponent over bacterial competitors. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000129139
Veröffentlicht am 29.01.2021
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 03.2021
Sprache Englisch
Identifikator ISSN: 1462-5814, 1462-5822
KITopen-ID: 1000129139
Erschienen in Cellular microbiology
Verlag Wiley
Band 23
Heft 3
Seiten Art.Nr. e13301
Vorab online veröffentlicht am 17.12.2020
Schlagwörter aspergillosis, defensin‐like peptide, fungal virulence
Nachgewiesen in Dimensions
Scopus
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