Electric propulsion (EP) systems offer considerably more degrees of freedom (DOFs) within the design process of aircraft compared to conventional aircraft engines. This requires large, computationally expensive design space explorations (DSE) with coupled models of the single components to incorporate interdependencies during optimization. The purpose of this paper is to exemplarily study these interdependencies of system key performance parameters (KPIs), e.g., system mass and efficiency, for a varying DC link voltage level of the power transmission system considering the example of the propulsion system of the CENTRELINE project, including an electric motor, a DC/AC inverter, and the DC power transmission cables. Each component is described by a physically derived, analytical model linking specific subdomains, e.g., electromagnetics, structural mechanics and thermal analysis, which are used for a coupled system model. This approach strongly enhances model accuracy and simultaneously keeps the computational effort at a low level. The results of the DSE reveal that the system KPIs improve for higher DC link voltage despite slightly inferior performance of motor and inverter as the mass of the DC power transmission cable has a major share for a an aircraft of the size as in the CENTRELINE project. ... mehrModeling of further components and implementation of optimization strategies will be part of future work.