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Co‐production of microbial lipids with valuable chemicals

Chen, Lin; Qian, Xiujuan; Zhang, Xiaoyu; Zhou, Xinhai; Zhou, Jie; Dong, Weiliang; Xin, Fengxue; Zhang, Wenming; Jiang, Min; Ochsenreither, Katrin

Abstract (englisch):
Microbial lipids are promising substitutes for petroleum and plant oil. However, the industrialization of microbial lipids is still limited and cannot compete with petrochemical petroleum due to its high production cost. Microorganisms capable of accumulating lipids and additional valuable chemicals are attractive for improving the economics of the microbial lipid production process. Compared with the increase in production of complex metabolic engineering to improve the overall economy, the multi‐chemical co‐production system is more advantageous in balancing the metabolic flux and optimal cell physiological recovery. In this review, various chemicals co‐produced with microbial lipids are classified according to their cell location. Efficient strategies, including the fermentation process and genetic engineering for regulating and enhancing such co‐production systems, are comprehensively discussed. The prospective and challenges during the scale‐up of lipids and valuable chemicals co‐production process are also highlighted.



Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 1932-104X, 1932-1031
KITopen-ID: 1000130767
Erschienen in Biofuels, bioproducts and biorefining
Verlag Wiley
Seiten Art.-Nr. bbb.2209
Vorab online veröffentlicht am 15.03.2021
Schlagwörter microbial lipids, co‐production strategy, oleaginous microorganisms, metabolic engineering, fermentation regulation
Nachgewiesen in Scopus
Web of Science
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