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Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging

Krell-Roesch, Janina 1; Syrjanen, Jeremy A.; Machulda, Mary M.; Christianson, Teresa J.; Kremers, Walter K.; Mielke, Michelle M.; Knopman, David S.; Petersen, Ronald C.; Vassilaki, Maria; Geda, Yonas E.
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)


Neuropsychiatric symptoms (NPS) are associated with the risk of incident mild cognitive impairment (MCI) and dementia. We examined associations between NPS and the outcomes of global and domain‐specific cognitive trajectories.

In this longitudinal study conducted in the setting of the population‐based Mayo Clinic Study of Aging, 5081 community‐dwelling, nondemented individuals aged ≥50 years (51% males) underwent NPS assessment using Neuropsychiatric Inventory Questionnaire (NPI‐Q), and Beck Depression and Anxiety Inventories (BDI‐II, BAI). Global and domain‐specific (memory, language, attention, and visuospatial skills) cognitive performance was assessed through neuropsychological testing every 15 months. Associations between baseline NPS and trajectories for individual yearly change in cognitive z‐scores were calculated using linear mixed‐effect models.

Cognition declined regardless of NPS status over the median follow‐up of 4.5 years. Presence of NPS was associated with increased cognitive decline. Differences in annualized change in global cognition z‐scores for participants with NPS compared to without NPS ranged from −0.018 (95% CI −0.032, −0.004; p = 0.011) for irritability to −0.159 (−0.254, −0.065; p = 0.001) for hallucinations. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000130959
Veröffentlicht am 25.04.2021
DOI: 10.1002/gps.5528
Zitationen: 5
Web of Science
Zitationen: 3
Zitationen: 7
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 0885-6230, 1099-1166
KITopen-ID: 1000130959
Erschienen in International journal of geriatric psychiatry
Verlag John Wiley and Sons
Vorab online veröffentlicht am 16.03.2021
Schlagwörter cognitive trajectory, longitudinal study, neuropsychiatric symptoms, nondemented, older adults
Nachgewiesen in Dimensions
Web of Science
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