Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging
Krell-Roesch, Janina
1; Syrjanen, Jeremy A.; Machulda, Mary M.; Christianson, Teresa J.; Kremers, Walter K.; Mielke, Michelle M.; Knopman, David S.; Petersen, Ronald C.; Vassilaki, Maria; Geda, Yonas E.
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)
1; Syrjanen, Jeremy A.; Machulda, Mary M.; Christianson, Teresa J.; Kremers, Walter K.; Mielke, Michelle M.; Knopman, David S.; Petersen, Ronald C.; Vassilaki, Maria; Geda, Yonas E.1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)
Abstract:
Objective
Neuropsychiatric symptoms (NPS) are associated with the risk of incident mild cognitive impairment (MCI) and dementia. We examined associations between NPS and the outcomes of global and domain‐specific cognitive trajectories.
Methods
In this longitudinal study conducted in the setting of the population‐based Mayo Clinic Study of Aging, 5081 community‐dwelling, nondemented individuals aged ≥50 years (51% males) underwent NPS assessment using Neuropsychiatric Inventory Questionnaire (NPI‐Q), and Beck Depression and Anxiety Inventories (BDI‐II, BAI). Global and domain‐specific (memory, language, attention, and visuospatial skills) cognitive performance was assessed through neuropsychological testing every 15 months. Associations between baseline NPS and trajectories for individual yearly change in cognitive z‐scores were calculated using linear mixed‐effect models.
Results
Cognition declined regardless of NPS status over the median follow‐up of 4.5 years. Presence of NPS was associated with increased cognitive decline. Differences in annualized change in global cognition z‐scores for participants with NPS compared to without NPS ranged from −0.018 (95% CI −0.032, −0.004; p = 0.011) for irritability to −0.159 (−0.254, −0.065; p = 0.001) for hallucinations. ... mehr
Neuropsychiatric symptoms (NPS) are associated with the risk of incident mild cognitive impairment (MCI) and dementia. We examined associations between NPS and the outcomes of global and domain‐specific cognitive trajectories.
Methods
In this longitudinal study conducted in the setting of the population‐based Mayo Clinic Study of Aging, 5081 community‐dwelling, nondemented individuals aged ≥50 years (51% males) underwent NPS assessment using Neuropsychiatric Inventory Questionnaire (NPI‐Q), and Beck Depression and Anxiety Inventories (BDI‐II, BAI). Global and domain‐specific (memory, language, attention, and visuospatial skills) cognitive performance was assessed through neuropsychological testing every 15 months. Associations between baseline NPS and trajectories for individual yearly change in cognitive z‐scores were calculated using linear mixed‐effect models.
Results
Cognition declined regardless of NPS status over the median follow‐up of 4.5 years. Presence of NPS was associated with increased cognitive decline. Differences in annualized change in global cognition z‐scores for participants with NPS compared to without NPS ranged from −0.018 (95% CI −0.032, −0.004; p = 0.011) for irritability to −0.159 (−0.254, −0.065; p = 0.001) for hallucinations. ... mehr
| Zugehörige Institution(en) am KIT | Institut für Sport und Sportwissenschaft (IfSS) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsmonat/-jahr | 09.2021 |
| Sprache | Englisch |
| Identifikator | ISSN: 0885-6230, 1099-1166 KITopen-ID: 1000130959 |
| Erschienen in | International journal of geriatric psychiatry |
| Verlag | John Wiley and Sons |
| Band | 36 |
| Heft | 9 |
| Seiten | 1362-1369 |
| Vorab online veröffentlicht am | 16.03.2021 |
| Schlagwörter | cognitive trajectory, longitudinal study, neuropsychiatric symptoms, nondemented, older adults |
| Nachgewiesen in | Dimensions Web of Science Scopus |