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Biophotonic sensors with integrated Si$_{3}$N$_{4}$-organic hybrid (SiNOH) lasers for point-of-care diagnostics

Kohler, Daria 1,2; Schindler, Gregor 2; Hahn, Lothar 2; Milvich, Johannes 1; Hofmann, Andreas 3; Länge, Kerstin 2; Freude, Wolfgang 1; Koos, Christian 1,2
1 Institut für Photonik und Quantenelektronik (IPQ), Karlsruher Institut für Technologie (KIT)
2 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
3 Institut für Automation und angewandte Informatik (IAI), Karlsruher Institut für Technologie (KIT)

Abstract:
Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection. Within this context, waveguide-(WG)-based optical biosensors on the silicon-nitride (Si$_{3}$N$_{4}$) platform represent a particularly promising option, offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range. However, while passive Si3N4-based photonic circuits lend themselves to highly scalable mass production, the integration of low-cost light sources remains a challenge. In this paper, we demonstrate optical biosensors that combine Si3N4 sensor circuits with hybrid on-chip organic lasers. These Si3N4-organic hybrid (SiNOH) lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source. Fabrication of the devices is simple: The underlying Si3N4 WGs are structured in a single lithography step, and the organic gain medium is subsequently applied by dispensing, spin-coating, or ink-jet printing processes. A highly parallel read-out of the optical sensor signals is accomplished with a simple camera. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000131376
Veröffentlicht am 16.04.2021
Originalveröffentlichung
DOI: 10.1038/s41377-021-00486-w
Scopus
Zitationen: 7
Web of Science
Zitationen: 7
Dimensions
Zitationen: 7
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Institut für Mikrostrukturtechnik (IMT)
Institut für Photonik und Quantenelektronik (IPQ)
Universität Karlsruhe (TH) – Interfakultative Einrichtungen (Interfakultative Einrichtungen)
Karlsruhe School of Optics & Photonics (KSOP)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2095-5545, 2047-7538
KITopen-ID: 1000131376
HGF-Programm 43.32.03 (POF IV, LK 01) Designed Optical Devices & Systems
Erschienen in Light: Science and Applications
Verlag Springer Nature [academic journals on nature.com]
Band 10
Heft 1
Seiten Art.-Nr.: 64
Vorab online veröffentlicht am 26.03.2021
Schlagwörter Biophotonics; Integrated optics; Lasers, LEDs and light sources; Optical sensors; Silicon photonics
Nachgewiesen in Dimensions
Scopus
Web of Science
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