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Platinum complexes in colorectal cancer and other solid tumors

Köberle, Beate 1; Schoch, Sarah
1 Institut für Toxikologie und Genetik (ITG), Karlsruher Institut für Technologie (KIT)

Abstract:

Cisplatin is one of the most commonly used drugs for the treatment of various solid neoplasms, including testicular, lung, ovarian, head and neck, and bladder cancers. Unfortunately, the therapeutic efficacy of cisplatin against colorectal cancer is poor. Various mechanisms appear to contribute to cisplatin resistance in cancer cells, including reduced drug accumulation, enhanced drug detoxification, modulation of DNA repair mechanisms, and finally alterations in cisplatin DNA damage signaling preventing apoptosis in cancer cells. Regarding colorectal cancer, defects in mismatch repair and altered p53-mediated DNA damage signaling are the main factors controlling the resistance phenotype. In particular, p53 inactivation appears to be associated with chemoresistance and poor prognosis. To overcome resistance in cancers, several strategies can be envisaged. Improved cisplatin analogues, which retain activity in resistant cancer, might be applied. Targeting p53-mediated DNA damage signaling provides another therapeutic strategy to circumvent cisplatin resistance. This review provides an overview on the DNA repair pathways involved in the processing of cisplatin damage and will describe signal transduction from cisplatin DNA lesions, with special attention given to colorectal cancer cells. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000132341
Veröffentlicht am 07.05.2021
Originalveröffentlichung
DOI: 10.3390/cancers13092073
Scopus
Zitationen: 40
Web of Science
Zitationen: 39
Dimensions
Zitationen: 45
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2072-6694
KITopen-ID: 1000132341
Erschienen in Cancers
Verlag MDPI
Band 13
Heft 9
Seiten Art.-Nr.: 2073
Nachgewiesen in Dimensions
Web of Science
Scopus
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