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Rebuilding the hematopoietic stem cell niche: Recent developments and future prospects

Chatterjee, Chandralekha; Schertl, Peter; Frommer, Miriam; Ludwig-Husemann, Anita; Mohra, Anna; Dilger, Nadine; Naolou, Toufik; Meermeyer, Sophia; Bergmann, Timna Claire; Alonso Calleja, Alejandro; Lee-Thedieck, Cornelia

Hematopoietic stem cells (HSCs) have proven their clinical relevance in stem cell transplantation to cure patients with hematological disorders. Key to their regenerative potential is their natural microenvironment – their niche – in the bone marrow (BM). Developments in the field of biomaterials enable the recreation of such environments with increasing preciseness in the laboratory. Such artificial niches help to gain a fundamental understanding of the biophysical and biochemical processes underlying the interaction of HSCs with the materials in their environment and the disturbance of this interplay during diseases affecting the BM. Artificial niches also have the potential to multiply HSCs in vitro, to enable the targeted differentiation of HSCs into mature blood cells or to serve as drug-testing platforms. In this review, we will introduce the importance of artificial niches followed by the biology and biophysics of the natural archetype. We will outline how 2D biomaterials can be used to dissect the complexity of the natural niche into individual parameters for fundamental research and how 3D systems evolved from them. We will present commonly used biomaterials for HSC research and their applications. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000133582
Veröffentlicht am 03.06.2021
DOI: 10.1016/j.actbio.2021.03.061
Zitationen: 8
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 15.09.2021
Sprache Englisch
Identifikator ISSN: 1742-7061, 1878-7568
KITopen-ID: 1000133582
HGF-Programm 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems
Erschienen in Acta Biomaterialia
Verlag Elsevier
Band 132
Seiten 129-148
Vorab online veröffentlicht am 01.04.2021
Nachgewiesen in Dimensions
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