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Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies

Klijn, Marieke E.; Hubbuch, Jürgen ORCID iD icon 1
1 Institut für Bio- und Lebensmitteltechnik (BLT), Karlsruher Institut für Technologie (KIT)


Imaging is increasingly more utilized as analytical technology in biopharmaceutical formulation research, with applications ranging from subvisible particle characterization to thermal stability screening and residual moisture analysis. This review offers a comprehensive overview of analytical imaging for scientists active in biopharmaceutical formulation research and development, where it presents the unique information provided by the ultraviolet (UV), visible (Vis), and infrared (IR) sections in the electromagnetic spectrum. The main body of this review consists of an outline of UV, Vis, and IR imaging techniques for several (bio)physical properties that are commonly determined during protein-based biopharmaceutical formulation characterization and development studies. The review concludes with a future perspective of applied imaging within the field of biopharmaceutical formulation research.

Verlagsausgabe §
DOI: 10.5445/IR/1000134262
Veröffentlicht am 23.06.2021
DOI: 10.1016/j.ejpb.2021.05.013
Zitationen: 9
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 0939-6411, 1873-3441
KITopen-ID: 1000134262
Erschienen in European Journal of Pharmaceutics and Biopharmaceutics
Verlag Elsevier
Band 165
Seiten 319-336
Schlagwörter Image processing; Machine learning; Formulation development; Protein analytics; High-throughput screening; Computer vision
Nachgewiesen in Dimensions
Web of Science
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