This research investigated influential factors on changes in networks of startups through a qualitative exploratory case study approach. Based on interviews with founders in Germany and selected stakeholders in entrepreneurial networks combined with a network mapping approach, we developed a framework of influential factors on network changes. In essence, this framework categorizes factors into sustainable resource acquisition, knowledge and skill acquisition, interpersonal factors, and interorganizational factors. Overall, our research contributes to a better understanding of factors that impact network changes by providing a construct with potential for theoretical standardization. In addition, this research offers important managerial implications.