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Impact of Nanocomposite Combustion Aerosols on A549 Cells and a 3D Airway Model

Hufnagel, Matthias 1,2; May, Nadine 3; Wall, Johanna 1,2; Wingert, Nadja; Garcia-Käufer, Manuel; Arif, Ali; Hübner, Christof; Berger, Markus; Mülhopt, Sonja ORCID iD icon 3; Baumann, Werner 3; Weis, Frederik; Krebs, Tobias; Becker, Wolfgang; Gminski, Richard; Stapf, Dieter 3; Hartwig, Andrea 1,2
1 Institut für Angewandte Biowissenschaften (IAB), Karlsruher Institut für Technologie (KIT)
2 Institut für Toxikologie und Genetik (ITG), Karlsruher Institut für Technologie (KIT)
3 Institut für Technische Chemie (ITC), Karlsruher Institut für Technologie (KIT)

Abstract:

The use of nanomaterials incorporated into plastic products is increasing steadily. By using nano-scaled filling materials, thermoplastics, such as polyethylene (PE), take advantage of the unique properties of nanomaterials (NM). The life cycle of these so-called nanocomposites (NC) usually ends with energetic recovery. However, the toxicity of these aerosols, which may consist of released NM as well as combustion-generated volatile compounds, is not fully understood. Within this study, model nanocomposites consisting of a PE matrix and nano-scaled filling material (TiO$_{2}$, CuO, carbon nano tubes (CNT)) were produced and subsequently incinerated using a lab-scale model burner. The combustion-generated aerosols were characterized with regard to particle release as well as compound composition. Subsequently, A549 cells and a reconstituted 3D lung cell culture model (MucilAir™, Epithelix) were exposed for 4 h to the respective aerosols. This approach enabled the parallel application of a complete aerosol, an aerosol under conditions of enhanced particle deposition using high voltage, and a filtered aerosol resulting in the sole gaseous phase. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000134470
Veröffentlicht am 28.06.2021
Originalveröffentlichung
DOI: 10.3390/nano11071685
Scopus
Zitationen: 4
Web of Science
Zitationen: 3
Dimensions
Zitationen: 5
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Institut für Technische Chemie (ITC)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 23.07.2021
Sprache Englisch
Identifikator ISSN: 2079-4991
KITopen-ID: 1000134470
HGF-Programm 38.05.01 (POF IV, LK 01) Anthropogenic Carbon Cycle
Weitere HGF-Programme 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Nanomaterials
Verlag MDPI
Band 11
Heft 7
Seiten Art. Nr.: 1685
Vorab online veröffentlicht am 27.06.2021
Schlagwörter nanocomposite; nano-enabled polymer (NEP); nanoparticles; air-liquid interface (ALI); nanotoxicology; incineration
Nachgewiesen in Web of Science
Dimensions
Scopus
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