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Circulating cell adhesion molecules in metabolically healthy obesity

Mulhem, Arij; Moulla, Yusef; Klöting, Nora; Ebert, Thomas; Tönjes, Anke; Fasshauer, Mathias; Dietrich, Arne; Schön, Michael R.; Stumvoll, Michael; Richter, Volker; Blüher, Matthias

Abstract:
Background/Objectives
People with metabolically healthy obesity (MHO) may still have an increased risk for cardiovascular mortality compared to metabolically healthy lean (MHL) individuals. However, the mechanisms linking obesity to cardiovascular diseases are not entirely understood. We therefore tested the hypothesis that circulating cell adhesion molecules (CAMs) are higher in MHO compared to MHL individuals.

Subjects/Methods
Serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), E-selectin and P-selectin were measured in age- and sex-matched groups of MHL (n = 32), MHO categorized into BMI-matched insulin sensitive (IS, n = 32) or insulin resistant (IR) obesity (n = 32) and people with metabolically unhealthy obesity (MUO, n = 32).

Results
Indeed, individuals with MHO have significantly higher sICAM-1, E-selectin, and P-selectin serum concentrations compared to MHL people. However, these CAMs are still significantly lower in IS compared to IR MHO. There was no difference between the groups in sVCAM-1 serum concentrations. Compared to all other groups, circulating adhesion molecules were significantly higher in individuals with MUO.
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Verlagsausgabe §
DOI: 10.5445/IR/1000134577
Veröffentlicht am 30.06.2021
Originalveröffentlichung
DOI: 10.1038/s41366-020-00667-4
Scopus
Zitationen: 10
Web of Science
Zitationen: 11
Dimensions
Zitationen: 11
Cover der Publikation
Zugehörige Institution(en) am KIT Fakultät für Elektrotechnik und Informationstechnik (ETIT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 02.2021
Sprache Englisch
Identifikator ISSN: 0307-0565, 1476-5497
KITopen-ID: 1000134577
Erschienen in International journal of obesity
Verlag Springer Nature [academic journals on nature.com]
Band 45
Heft 2
Seiten 331–336
Vorab online veröffentlicht am 01.09.2020
Nachgewiesen in Scopus
Dimensions
Web of Science
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