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Discovery of a size-record breaking green-emissive fluorophore: small, smaller, HINA

Kang, Rui 1; Talamini, Laura; D'Este, Elisa; Estevão, Bianca Martins; De Cola, Luisa 1; Klopper, Wim 2; Biedermann, Frank 1
1 Karlsruher Institut für Technologie (KIT)
2 Institut für Physikalische Chemie (IPC), Karlsruher Institut für Technologie (KIT)

Abstract:

Astonishingly, 3-hydroxyisonicotinealdehyde (HINA) is despite its small size a green-emitting push–pull fluorophore in water (QY of 15%) and shows ratiometric emission response to biological relevant pH differences (pK$_{a2}$ ∼ 7.1). Moreover, HINA is the first small-molecule fluorophore reported that possesses three distinctly emissive protonation states. This fluorophore can be used in combination with metal complexes for fluorescent-based cysteine detection in aqueous media, and is readily taken up by cells. The theoretical description of HINA's photophysics remains challenging, even when computing Franck–Condon profiles via coupled-cluster calculations, making HINA an interesting model for future method development.


Verlagsausgabe §
DOI: 10.5445/IR/1000134579
Veröffentlicht am 30.06.2021
Originalveröffentlichung
DOI: 10.1039/d0sc05557c
Scopus
Zitationen: 3
Web of Science
Zitationen: 2
Dimensions
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2041-6520, 2041-6539
KITopen-ID: 1000134579
HGF-Programm 43.32.01 (POF IV, LK 01) Molecular Materials Basis for Optics & Photonics
Erschienen in Chemical science
Verlag Royal Society of Chemistry (RSC)
Band 12
Heft 4
Seiten 1392–1397
Nachgewiesen in Web of Science
Scopus
Dimensions
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