Low information exchange in global production networks results in long response time to disruption and negative performance impact. Digitalization enables a more intensive information exchange. This paper analyses the performance of order management, quality problem resolution and engineering change management in production networks with respect to different disruptions and information flows. Causeeffect relationships are revealed based on a multi-method simulation model and statistical experiments. Using surrogate modelling and robust optimization, a target picture for information exchange is determined. The benefits of the approach are demonstrated using a case study for the production of metal-plastic parts for the automotive supplier industry.