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A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy

Sánchez Arciniegas, Jorge Patricio

Abstract:

Atrial fibrillation is the most common cardiac arrhythmia. During atrial fibrillation, the atrial substrate undergoes a series of electrical and structural remodeling processes. The electrical remodeling is characterized by the alteration of specific ionic channels, which changes the morphology of the transmembrane voltage known as action potential. Structural remodeling is a complex process involving the interaction of several signalling pathways, cellular interaction, and changes in the extracellular matrix. During structural remodeling, fibroblasts, abundant in the cardiac tissue, start to differentiate into myofibroblasts, which are responsible for maintaining the extracellular matrix structure by depositing collagen. Additionally, myofibroblasts paracrine signalling with surrounding myocytes will also affect ionic channels.

Highly detailed computational models at different scales were used to study the effect of structural remodeling induced at the cellular and tissue levels. At the cellular level, a human fibroblast model was adapted to reproduce the myofibroblast electrophsyiology during atrial fibrillation. Additionally, the calcium handling in myofibroblast electrophysiology was assessed by fitting a calcium ion channel to experimental data. ... mehr


Volltext §
DOI: 10.5445/IR/1000134665
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Hochschulschrift
Publikationsdatum 09.07.2021
Sprache Englisch
Identifikator KITopen-ID: 1000134665
Verlag Karlsruher Institut für Technologie (KIT)
Umfang xviii, 108 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Elektrotechnik und Informationstechnik (ETIT)
Institut Institut für Biomedizinische Technik (IBT)
Prüfungsdatum 24.06.2021
Schlagwörter cardiac modeling, atrial fibrillation, fibrosis, myofibroblast
Relationen in KITopen
Referent/Betreuer Dössel, O.
Trenor, B. A. Gomis
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