In high-power fusion gyrotrons, the maximum heat-load on the wall of the interaction section is in the order of 2 kW/cm2, which is the major limiting technological factor for output power and pulse-length of the tube. The ongoing gyrotron development demands a very effective cavity cooling system for optimum gyrotron operation. In this work, the experimental investigation of a mini-channel cavity cooling using a mock-up test set-up is described. The mock-up test set-up will be used to experimentally validate the predictive simulation results and verify the mini-channel cooling performance. It is crucial for validation of the mini-channel cooling properties to determine the amount of the heat load introduced in the cavity wall by an induction heater. In order to estimate that heat load, full 3D electromagnetic simulations have been performed using the CST Studio Suite® software. A suitable calibration factor for the load deposited in the mock-up inner wall is identified after numerical investigation by a 3D thermal model. Calorimetry measurements are performed and the experimental results are compared with the simulation results obtained with a 3D thermal-hydraulic model, using the commercial software STAR-CCM+. ... mehrWhen the calibration factor is applied, the experimental calorimetry is well reproduced by the simulations.