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Integration of a semi-automatic in-vitro RFA procedure into an experimental setup

Pollnow, Stefan; Busch, Lisa-Mareike; Wülfers, Eike Moritz; Arnold, Robert; Dössel, Olaf


Radiofrequency ablation (RFA) is a standard clinical procedure for treating many cardiac arrhythmias. In order to increase the success rate of this treatment, the evaluation of lesion development with the help of intracardiac electrogram (EGM) criteria has to be improved further. We are investigating in-vitro the electrophysiological characteristics of cardiac tissue by using fluorescence-optical and electrical techniques. In this project, it is intended to create ablation lesions under defined conditions in rat atria or ventricle and to determine the electrical activity in the myocardium surrounding these lesions less than 1 s after the ablation. Therefore, we developed a semi-automatic RFA procedure, which was integrated into an existing experimental setup. Firstly, a controllable protection circuit board was designed to galvanically isolate the sensitive amplifiers for measuring extracellular potentials during the ablation. Secondly, a real-time system was implemented to control and to autonomously monitor the RFA procedure. We verified each component as well as the different sequences of the RFA procedure. In conclusion, the expanded setup will be used in future in-vitro experiments to determine new EGM criteria to assess lesion formation during the RFA procedure.

Verlagsausgabe §
DOI: 10.5445/IR/1000135286
Veröffentlicht am 13.07.2021
DOI: 10.1515/cdbme-2016-0020
Zitationen: 1
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Universität Karlsruhe (TH) – Interfakultative Einrichtungen (Interfakultative Einrichtungen)
Karlsruhe School of Optics & Photonics (KSOP)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2016
Sprache Englisch
Identifikator ISSN: 2364-5504
KITopen-ID: 1000135286
Erschienen in Current directions in biomedical engineering
Verlag De Gruyter
Band 2
Heft 1
Seiten 77–81
Schlagwörter ablation lesion; extracellular potentials; in-vitro experiments; radiofrequency ablation
Nachgewiesen in Dimensions
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