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TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication

Pauletto, Eleonora 1,2; Eickhoff, Nils; Padrão, Nuno; Blattner, Christine 1,2; Zwart, Wilbert
1 Institut für Technik der Informationsverarbeitung (ITIV), Karlsruher Institut für Technologie (KIT)
2 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)


The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple diseases including cancer. With hormone-driven cancers being among the leading causes of cancer-related death, TRIM proteins have been described to portrait tumor suppressive or oncogenic activities in these tumor types. This review describes the biological impact of TRIM proteins in relation to hormone receptor biology, as well as hormone-independent mechanisms that contribute to tumor cell biology in prostate, breast, ovarian and endometrial cancer. Furthermore, we point out common functions of TRIM proteins throughout the group of hormone-driven cancers. An improved understanding of the biological impact of TRIM proteins in cancer may pave the way for improved prognostication and novel therapeutics, ultimately improving cancer care for patients with hormone-driven cancers.

Verlagsausgabe §
DOI: 10.5445/IR/1000135752
Veröffentlicht am 22.07.2021
DOI: 10.3390/cells10061517
Zitationen: 10
Web of Science
Zitationen: 10
Zitationen: 11
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 06.2021
Sprache Englisch
Identifikator ISSN: 2073-4409
KITopen-ID: 1000135752
HGF-Programm 47.14.02 (POF IV, LK 01) Information Storage and Processing in the Cell Nucleus
Erschienen in Cells
Verlag MDPI
Band 10
Heft 6
Seiten Art.-Nr.: 1517
Bemerkung zur Veröffentlichung This article belongs to the Special Issue Cellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease.
Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 16.06.2021
Schlagwörter TRIM proteins; hormone-related cancers; E3 ligases; ubiquitin; RING; steroid hormones
Nachgewiesen in Scopus
Web of Science
Globale Ziele für nachhaltige Entwicklung Ziel 3 – Gesundheit und Wohlergehen
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