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Fluorescence detected circular dichroism (FDCD) for supramolecular host–guest complexes

Prabodh, Amrutha ORCID iD icon 1; Wang, Yichuan 2; Sinn, Stephan 1; Albertini, Paolo; Spies, Christian; Spuling, Eduard 2; Yang, Liu-Pan; Jiang, Wei; Bräse, Stefan 2; Biedermann, Frank 1
1 Karlsruher Institut für Technologie (KIT)
2 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)

Abstract:

Fluorescence-detected circular dichroism (FDCD) spectroscopy is applied for the first time to supramolecular host–guest and host–protein systems and compared to the more known electronic circular dichroism (ECD). We find that FDCD can be an excellent choice for common supramolecular applications, e.g. for the detection and chirality sensing of chiral organic analytes, as well as for reaction monitoring. Our comprehensive investigations demonstrate that FDCD can be conducted in favorable circumstances at much lower concentrations than ECD measurements, even in chromophoric and auto-emissive biofluids such as blood serum, overcoming the sensitivity limitation of absorbance-based chiroptical spectroscopy. Besides, the combined use of FDCD and ECD can provide additional valuable information about the system, e.g. the chemical identity of an analyte or hidden aggregation phenomena. We believe that simultaneous FDCD- and ECD-based chiroptical characterization of emissive supramolecular systems will be of general benefit for characterizing fluorescent, chiral supramolecular systems due to the higher information content obtained by their combined use.


Verlagsausgabe §
DOI: 10.5445/IR/1000135806
Veröffentlicht am 23.07.2021
Originalveröffentlichung
DOI: 10.1039/d1sc01411k
Scopus
Zitationen: 15
Web of Science
Zitationen: 16
Dimensions
Zitationen: 20
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Institut für Nanotechnologie (INT)
Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2041-6520, 2041-6539
KITopen-ID: 1000135806
HGF-Programm 43.31.02 (POF IV, LK 01) Devices and Applications
Erschienen in Chemical science
Verlag Royal Society of Chemistry (RSC)
Band 12
Heft 27
Seiten 9420–9431
Nachgewiesen in Scopus
Dimensions
Web of Science
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