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Soft but not too soft—How a rigid tube expands without breaking

Wernet, Valentin 1; Herrero, Satur 1; Fischer, Reinhard 1
1 Karlsruher Institut für Technologie (KIT)


Fungi grow by apical extension of their hyphae. The continuous growth requires constant delivery of vesicles, which fuse with the membrane and secrete cell wall biosynthesis enzymes. The growth mechanism requires the fungal cytoskeleton and turgor pressure. In a recent study by Fukuda et al. (mBio 12:e03196-20, 2021,, hyphal growth was studied in microfluidic devices with channels smaller than the hyphal diameter. The authors discovered that fast-growing fungi like Neurospora crassa enter the channels, but hyphal tips become fragile and rupture frequently, whereas slower-growing fungi like Aspergillus nidulans adapt their hyphal diameter and grow without problems through the channels. This study suggests two different growth mechanisms and a tradeoff between hyphal plasticity and growth speed.

Verlagsausgabe §
DOI: 10.5445/IR/1000135844
Veröffentlicht am 27.07.2021
DOI: 10.1128/mBio.00501-21
Zitationen: 1
Web of Science
Zitationen: 1
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2161-2129
KITopen-ID: 1000135844
Erschienen in mBio
Band 12
Heft 3
Seiten e00501-21
Nachgewiesen in Web of Science
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