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Monitoring Solid-Phase Reactions in Self-Assembled Monolayers by Surface-Enhanced Raman Spectroscopy

Scherrer, Dominik; Vogel, David; Drechsler, Ute; Olziersky, Antonis; Sparr, Christof; Mayor, Marcel 1; Lörtscher, Emanuel
1 Karlsruher Institut für Technologie (KIT)


Nanopatterned surfaces enhance incident electromagnetic radiation and thereby enable the detection and characterization of self-assembled monolayers (SAMs), for instance in surface-enhanced Raman spectroscopy (SERS). Herein, Au nanohole arrays, developed and characterized as SERS substrates, are exemplarily used for monitoring a solid-phase deprotection and a subsequent copper(I)-catalyzed azide–alkyne cycloaddition “click” reaction, performed directly on the corresponding SAMs. The SERS substrate was found to be highly reliable in terms of signal reproducibility and chemical stability. Furthermore, the intermediates and the product of the solid-phase synthesis were identified by SERS. The spectra of the immobilized compounds showed minor differences compared to spectra of the microcrystalline solids. With its uniform SERS signals and the high chemical stability, the platform paves the way for monitoring molecular manipulations in surface functionalization applications.

Verlagsausgabe §
DOI: 10.5445/IR/1000136006
Veröffentlicht am 30.07.2021
DOI: 10.1002/anie.202102319
Zitationen: 13
Web of Science
Zitationen: 12
Zitationen: 15
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 1433-7851, 0570-0833, 1521-3773
KITopen-ID: 1000136006
HGF-Programm 43.32.01 (POF IV, LK 01) Molecular Materials Basis for Optics & Photonics
Erschienen in Angewandte Chemie - International Edition
Verlag John Wiley and Sons
Band 60
Heft 33
Seiten 17981-17988
Bemerkung zur Veröffentlichung This article also appears in: Hot Topic: Click Chemistry
Vorab online veröffentlicht am 28.05.2021
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