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Kinetic analysis of the partial synthesis of artemisinin: Photooxygenation to the intermediate hydroperoxide

Triemer, S.; Schulze, M.; Wriedt, B.; Schenkendorf, R.; Ziegenbalg, D.; Krewer, U. ORCID iD icon 1; Seidel-Morgenstern, A.
1 Institut für Angewandte Materialien – Keramische Werkstoffe und Technologien (IAM-KWT1), Karlsruher Institut für Technologie (KIT)

Abstract:

The price of the currently best available antimalarial treatment is driven in large part by the limited availability of its base drug compound artemisinin. One approach to reduce the artemisinin cost is to efficiently integrate the partial synthesis of artemisinin starting from its biological precursor dihydroartemisinic acid (DHAA) into the production process. The optimal design of such an integrated process is a complex task that is easier to solve through simulations studies and process modelling. In this article, we present a quantitative kinetic model for the photooxygenation of DHAA to an hydroperoxide, the essential initial step of the partial synthesis to artemisinin. The photooxygenation reactions were studied in a two-phase photo-flow reactor utilizing Taylor flow for enhanced mixing and fast gas-liquid mass transfer. A good agreement of the model and the experimental data was achieved for all combinations of photosensitizer concentration, photon flux, fluid velocity and both liquid and gas phase compositions. Deviations between simulated predictions and measurements for the amount of hydroperoxide formed are 7.1 % on average. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000136150
Veröffentlicht am 13.08.2021
Originalveröffentlichung
DOI: 10.1007/s41981-021-00181-2
Scopus
Zitationen: 3
Web of Science
Zitationen: 2
Dimensions
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Materialien – Elektrochemische Technologien (IAM-ET1)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2021
Sprache Englisch
Identifikator ISSN: 2062-249X, 2063-0212
KITopen-ID: 1000136150
Erschienen in Journal of Flow Chemistry
Verlag Akadémiai Kiadó
Band 11
Seiten 641–659
Vorab online veröffentlicht am 13.07.2021
Nachgewiesen in Dimensions
Scopus
Web of Science
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