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Microdosing for drug delivery application—A review

Bußmann, Agnes Beate ORCID iD icon 1; Grünerbel, Lorenz Maximilian; Durasiewicz, Claudia Patricia; Thalhofer, Thomas Alexander; Wille, Axel; Richter, Martin
1 Karlsruher Institut für Technologie (KIT)


There is an increasing amount of research on microfluidic actuators with the aim to improve drug dosing applications. Micropumps are promising as they reduce the size and energy consumption of dosing concepts and enable new therapies. Even though there are evident advantages, there are only few examples of industrial microdosing units and micropump technology has not yet found widespread application. To answer the evoked question of what limits the application of microdosing technology for drug delivery, this work provides a comprehensive insight into the subject of drug dosing. We highlight and analyse specific microfluidic challenges and requirements in medical dosing: safety relevant aspects, such as prevention of freeflow and backflow; dosing-specific requirements, such as dosing precision and stability; and system-specific aspects, such as size, weight, and power restrictions or economic aspects. Based on these requirements, we evaluate the suitability of different mechanical micropumps and actuation mechanisms for drug administration. In addition to research work, we present industrial microdosing systems that are commercially available or close to market release. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000136791
Veröffentlicht am 03.08.2022
DOI: 10.1016/j.sna.2021.112820
Zitationen: 26
Web of Science
Zitationen: 22
Zitationen: 27
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 15.10.2021
Sprache Englisch
Identifikator ISSN: 0924-4247
KITopen-ID: 1000136791
Erschienen in Sensors and actuators <Lausanne> / A
Verlag Elsevier
Band 330
Seiten Art. Nr.: 112820
Schlagwörter Micropump, Microdosing, Microactuation, Drug delivery, Patch pumps, Medical dosing application, Microfluidic
Nachgewiesen in Dimensions
Web of Science
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