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Solvent‐induced enantioselectivity reversal in a chiral metal organic framework

Slater, Benjamin D.; Hill, Matthew R.; Ladewig, Bradley P. 1
1 Institut für Mikroverfahrenstechnik (IMVT), Karlsruher Institut für Technologie (KIT)

Abstract:

Solvent-induced enantioselectivity reversal is a rarely reported phenomenon in porous homochiral materials. Similar behavior has been studied in chiral high performance liquid chromatography, where minor modifications to the mobile phase can induce elution order reversal of two enantiomers on a chiral stationary phase column. We report the first instance of solvent-induced enantioselectivity reversal in a homochiral metal organic framework. Further, we highlight the complex enantioselectivity behavior of homochiral metal organic frameworks toward racemic mixtures in the presence of solvents through racemate-solvent enantioselectivity and loading experiments as well as enantiopure-solvent loading experiments. We hypothesize that this interesting selectivity reversal behavior is likely to be observed in other competitive adsorption, nonchiral selective processes involving a solvent.


Verlagsausgabe §
DOI: 10.5445/IR/1000136828
Veröffentlicht am 26.08.2021
Originalveröffentlichung
DOI: 10.1002/jssc.202100322
Scopus
Zitationen: 9
Dimensions
Zitationen: 10
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikroverfahrenstechnik (IMVT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2021
Sprache Englisch
Identifikator ISSN: 1615-9306, 1615-9314
KITopen-ID: 1000136828
HGF-Programm 38.03.02 (POF IV, LK 01) Power-based Fuels and Chemicals
Erschienen in Journal of separation science
Verlag Wiley-VCH Verlag
Band 44
Heft 17
Seiten 3319-3323
Vorab online veröffentlicht am 10.07.2021
Schlagwörter enantioseparation, metal organic framework, selectivity reversal, separation
Nachgewiesen in Scopus
Dimensions
Web of Science
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