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Sex-specific Relationship between the Cardiorespiratory Fitness and Plasma Metabolite Patterns in Healthy Humans—Results of the KarMeN Study

Kistner, S.; Döring, M.; Krüger, R.; Rist, M. J.; Weinert, C. H.; Bunzel, D.; Merz, B.; Radloff, K.; Neumann, R. 1; Härtel, S. 1; Bub, A. 1
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)


Cardiorespiratory fitness (CRF) represents a strong predictor of all-cause mortality and is strongly influenced by regular physical activity (PA). However, the biological mechanisms involved in the body’s adaptation to PA remain to be fully elucidated. The aim of this study was to systematically examine the relationship between CRF and plasma metabolite patterns in 252 healthy adults from the cross-sectional Karlsruhe Metabolomics and Nutrition (KarMeN) study. CRF was determined by measuring the peak oxygen uptake during incremental exercise. Fasting plasma samples were analyzed by nuclear magnetic resonance spectroscopy and mass spectrometry coupled to one- or two-dimensional gas chromatography or liquid chromatography. Based on this multi-platform metabolomics approach, 427 plasma analytes were detected. Bi- and multivariate association analyses, adjusted for age and menopausal status, showed that CRF was linked to specific sets of metabolites primarily indicative of lipid metabolism. However, CRF-related metabolite patterns largely differed between sexes. While several phosphatidylcholines were linked to CRF in females, single lyso-phosphatidylcholines and sphingomyelins were associated with CRF in males. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000136945
Veröffentlicht am 06.09.2021
DOI: 10.3390/metabo11070463
Zitationen: 7
Web of Science
Zitationen: 6
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2218-1989
KITopen-ID: 1000136945
Erschienen in Metabolites
Verlag MDPI
Band 11
Heft 7
Seiten Art. Nr.: 463
Vorab online veröffentlicht am 17.07.2021
Schlagwörter cardiorespiratory fitness; physical fitness; metabolomics; plasma metabolome; plasma metabolite patterns; metabolite profiles
Nachgewiesen in Dimensions
Web of Science
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