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A compact system for intraoperative specimen imaging based on edge illumination x-ray phase contrast

Havariyoun, Glafkos; Vittoria, Fabio A.; Hagen, Charlotte K.; Basta, Dario; Kallon, Gibril K.; Endrizzi, Marco; Massimi, Lorenzo; Munro, Peter; Hawker, Sam; Smit, Bennie; Astolfo, Alberto; Larkin, Oliver J.; Waltham, Richard M.; Shah, Zoheb; Duffy, Stephen W.; Nelan, Rachel L.; Peel, Anthony; Suaris, Tamara; Jones, J. Louise; ... mehr


A significant number of patients receiving breast-conserving surgery (BCS) for invasive carcinoma and ductal carcinoma in situ (DCIS) may need reoperation following tumor-positive margins from final histopathology tests. All current intraoperative margin assessment modalities have specific limitations. As a first step towards the development of a compact system for intraoperative specimen imaging based on edge illumination x-ray phase contrast, we prove that the system's dimensions can be reduced without affecting imaging performance.

We analysed the variation in noise and contrast to noise ratio (CNR) with decreasing system length using the edge illumination x-ray phase contrast imaging setup. Two-(planar) and three-(computed tomography (CT)) dimensional imaging acquisitions of custom phantoms and a breast tissue specimen were made. Dedicated phase retrieval algorithms were used to separate refraction and absorption signals. A 'single-shot' retrieval method was also used, to retrieve thickness map images, due to its simple acquisition procedure and reduced acquisition times. Experimental results were compared to numerical simulations where appropriate.
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Verlagsausgabe §
DOI: 10.5445/IR/1000137140
Veröffentlicht am 02.09.2021
DOI: 10.1088/1361-6560/ab4912
Zitationen: 14
Web of Science
Zitationen: 14
Zitationen: 18
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Beschleunigerphysik und Technologie (IBPT)
Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 1361-6560
KITopen-ID: 1000137140
HGF-Programm 54.01.01 (POF III, LK 01) ps- und fs-Strahlen
Erschienen in Physics in medicine and biology
Verlag Institute of Physics Publishing Ltd (IOP Publishing Ltd)
Band 64
Heft 23
Seiten Art.-Nr.: 235005
Vorab online veröffentlicht am 26.11.2019
Nachgewiesen in Scopus
Web of Science
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